PHYSCI 5 Lecture Notes - Lecture 19: Tow Truck, Cardiovascular Disease, Blood Vessel

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19 Jun 2018
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Lipid Transportation
Chylomicrons : Triglycerides and cholesterol
Vesicles that carry dietary fats //fat that we eat
Small intestine → liver
In Liver - store fat or shuttle to where needed
● HDL*
● VLDL
Originates in the liver and travels to body cells
Lots of triglycerides and cholesterol
As it travels from point A to B, starts to unload → release bit by bit → less
triglycerides
Bus becomes emptier → starts at liver and is packed with triglycerides → after a
while it becomes less triglycerides and more cholesterol
LDL low density lipoprotein -- has less triglycerides and more cholesterol
Ideally, LDL end in the liver
But gets stuck in blood vessel → broken up but then it gets stuck on the
side of the cell → plaque and crease diameter of blood besel and slow
things down
LDL culprit of cardiovascular disease - look at LDL levels → risk of
cardiovascular disease with amt of LDL
Every individuals have LDL, and cholesterol is important chemical found
in every cell → for membrane flexibility and vitamin synthesis and steroid
hormone synthesis
BUT high amount makes it dangerous
High cholesterol in blood is bad /// LDL → get stuck in blood vessel →
cardiovascular diseases
High amount of it gets stuck in the blood vessels
Flow of blood through blood vessel isn’t affected yet, just have little bit of
cholesterol , flow of blood is normal → no major problems → car stuck on side of
road but there’s no flow impedance
As more blood gets stuck, raise alarm
As more and more gets stuck and left alone, LDL oxidation →
neighboring cells are marking those LDL (mark) to call the cleaning crew,
something is wrong :O → cells oxidize LDL someone calling for help.
Tow truck comes in 2 levels → to remove LDL you call
1. Important form of cholesterol HDL // good cholesterol
Want this to be high
HDL removes cholesterol from blood and returns to liver
2. Immune cells called Macrophages
Remove the oxidized materials because they aren't supposed to
be there
Inflammation - recruiting macrophages
Back to where macrophages themselves breakdown
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PHYSCI 5 Full Course Notes
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Document Summary

Vesicles that carry dietary fats //fat that we eat. In liver - store fat or shuttle to where needed. Originates in the liver and travels to body cells. As it travels from point a to b, starts to unload release bit by bit less triglycerides. Bus becomes emptier starts at liver and is packed with triglycerides after a while it becomes less triglycerides and more cholesterol. Ldl low density lipoprotein -- has less triglycerides and more cholesterol. But gets stuck in blood vessel broken up but then it gets stuck on the side of the cell plaque and crease diameter of blood besel and slow things down. Ldl culprit of cardiovascular disease - look at ldl levels risk of cardiovascular disease with amt of ldl. Every individuals have ldl, and cholesterol is important chemical found in every cell for membrane flexibility and vitamin synthesis and steroid hormone synthesis.

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