ANSC 3323 Lecture Notes - Lecture 1: Somatic Cell Nuclear Transfer, Allotransplantation, Organ Transplantation
Document Summary
How does transgenics work: transfer of injected egg into surrogate mothers, screen offspring for expression of a transgene, transgene is then inherited in a mendelian fashion. Why transgenics: bioreactors insulin, etc. Use of plant/animal genome to apply to medical issues in the human genome: organ/cell/tissue donors. Pigs are physiologically closest to humans (we can use pig-organs for human transplantation) We have to insert some human genes into the pig to fool" human body into not attacking foreign organ transplant: basic research/disease model. Insert human genes into different animals and observe the effect to find the function of that gene, etc. Gmos don"t cause cancer!: gmos are only 20 years" old, no one has died from gmo-related cancer ever. Xenotransplantation: transplanting organ from one-species to another, allotransplantation same species to same species organ transplantation, severe organ shortage if we do not utilize this, organ failure in humans 100,000 cases a year.