ANSC 3316 Lecture Notes - Lecture 4: Bioassay, Prostate, Signal Transduction

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13 Apr 2017
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Has to cause physiological change in cell. Hormone mechanism of action: what is amount of" action based on. Concentration of hormone in blood (concentration in blood, never a level in blood) Hormones are usually in nanogram picogram amounts (next to nothing) Amount of hormone (first critically important aspect of hormone action) in blood is a function of. + clearance rate (how fast hormone is metabolized) + biological availability (can it be used or bind to the cell in question?) Often times, it is not biologically available. Free hormone most of the time is readily biologically available. Bound hormone not readily biologically available and therefore has a lower clearance rate, etc. etc. Changes rapidly in response to different external and internal factors. You collect a blood sample, never a blood draw. + the higher the specificity of the receptor for a hormone, the higher the action. The binding of hormone to receptor causes a physiological response.

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