BIOL 1107 Lecture Notes - Lecture 6: Anaerobic Respiration, Mitochondrion, Electrochemical Gradient

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10 Jul 2016

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Glucose is preferred molecule for atp production. One molecule of atp is produced from glycolysis. Nadh (an electron carrier) is created and carries electrons to the proton gradient at the end. 2 pyruvate molecules are created for every one glucose molecule. This is because glucose has 6 carbons, which split into two molecules of 3 carbons each. Pyruvate processing releases co2 and more nadh. Releasing co2 allows the molecule to fit into the citric acid cycle because a carbon was taken out (was too large with 3 carbons) Acetyl coa (a 2 carbon molecule) is produced from each pyruvate. The citric acid cycle is continuous (no end point) Atp is produced in this cycle (oxidative phosphorylation) Glycolysis is a series of 10 chemical reactions. Enzymes are used to lower activation energy, then atp is used to begin glycolysis (no heat involved in glycolysis) Start with a glucose molecule, give it atp (phosphorylate it) to give it energy.

Related Questions

Which of the following is not a net product of the citric acid cycle for each molecule of pyruvate generated in glycolysis?

Select one:

a. 1 ATP (GTP)

b. 1 acetyl coA

c. 3 NADH

d. 1 FADH2

Question 2

Which of the following is NOT an end product for an acetyl group that enters the citric acid cycle?

Select one:

a. ATP

b. NADH

c. FADH2

d. oxaloacetate

Question 3

Once they have been processed through the citric acid cycle, the acetyl-CoA molecules from a single glucose molecule produce:

Select one:

a. 2 ATP, 6 NADH, 4 CO₂.

b. 6 NADH, 6 GTP.

c. 6 FADH₂, 2 ATP, 6 CO₂.

d. 6 GTP, 6 FADH₂.

e. 4 CO₂, 6 FADH₂, 2 ATP.

Question 4

The products of the citric acid cycle breaking down 2 acetyl-CoA include 2 ATP (converted from GTP), 6 NADH and 2 FADH2.

Select one:

True

False

1. Integrated metabolism

A. A molecule of glucose that you eat can eventually be transformed into part of a fatty acid that you store. Circle the pathways/cycles below that are part of this overall flow of carbon atoms. Cross out any that are not.

Gluconeogenesis, beta-oxidation, citric acid cycle, glycolysis, urea cycle, fatty acid synthesis

B. Trace the metabolic path of this glucose molecule through the enzymes it encounters along the way to being made into fat. Write all the enzymes in the list below into the proper places in the figure below. If the enzyme is not used, write its name in a ânot used" column. If it is used, write the enzyme in the order that the carbon atoms from glucose encounter the enzymes.

Pyruvate dehydrogenase, fumarase, aldolase, lactate dehydrogenase, pyruvate kinase, acetyl CoA carboxylase, fatty acid synthase, hexokinase, carnitine acyltransferase, ATP synthase

B. What is the minimum number of glucose molecules that would be necessary to be the carbon source for synthesis of a 16-carbon fatty acid through this pathway?

C. How many net glucose can be made from one molecule of a 16-carbon fatty acid?

2. Describe each cycle/transport system (compounds, compartments, tissues) and explain its purpose:

A. citrate transport system

B. Cori cycle

C. glucose/alanine cycle

Explain the logic of these pathway regulations:

A. Phosphofructokinase, not hexokinase, is the main regulation site of glycolysis.

B. SuccinylCoA inhibits the entry of acetyl CoA into the citric acid cycle.

C. NADH inhibits pyruvate dehydrogenase.

D. Citrate inhibits the citric acid cycle and activates acetyl-CoA carboxylase.

E. Insulin leads to activation of glycogen synthase.

ochrereindeer904

The reduced nucleotides NADH and FADH are converted to ATP via the electron transport chain and oxidative phosphorylation. The most widely accepted values among biochemists are shown.

Nucleotide Output	ATP Output
NADH	2.5
FADH₂	1.5

Each acetyl CoA entering the citric acid cycle produces two CO₂, three NADH, one FADH₂, and one GTP (converted directly to ATP in the cell). Taking into consideration the conversion of reduced nucleotides to ATP, what is the total number of ATP produced by one glucose (2 Acteyl CoA) going through the citric acid cycle?

BIOL 1107 Lecture Notes - Lecture 6: Anaerobic Respiration, Mitochondrion, Electrochemical Gradient

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