MCB 2410 Lecture Notes - Lecture 3: Chromosomal Inversion, Monosomy, Polyploid

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One or more complete sets of chromosomes. Alters a characteristic due to unbalanced gene dosage. Paracentric inversion - does not include the centromere. Abcd*efg adcb*efg (paracentric inversion of bcd) Abcd*efg abe*dcfg (pericentric inversion of cd*e) May lead to alteration in gene function and regulation. Translocation - movement of genetic material between nonhomologous chromosomes. Loss of one member of the homologous pair. One additional member of an homologous pair. Nondisjunction - the failure of homologous chromosomes to properly segregate. Proper number and kind of chromosomes are required for proper development. Nondisjunction in meiosis i results in 4 abnormal gametes. Nondisjunction in meiosis ii results in 2 normal gametes and 2 abnormal gametes. Nondisjunction of sex chromosomes (x and y are pairing partners that normally segregate) Imbalance in sex chromosomes is less damaging than an imbalance in an autosome. Random x inactivation - only 1 x is in the active state while all others are inactive and condensed into barr bodies.

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