MCB 2610 Lecture Notes - Lecture 10: Tobacco Mosaic Virus, Mimivirus, Base Pair
25 May 2018
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Virusβ natural reservoirs are from birds, pigs, ducks !
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Infectious Cycle
Virus starts out in extracellular form : virions bind to host cell and get its genome into the host. The host cell is then infected β’
and new particles are being made from the genetic material from the original infecting virus. Virus replicates and release by
lysis of host cell. !
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A lot of variety in what type of genome they have
DNA βββ-> ds DNA (herpes) !
#ββββ> ss DNA (bacteriophage M13) # !
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RNA ββββ> ds RNA (Reoviruses) !
ββββ> ss RNA (Inο¬uenza) !
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Virus can be !β’
+small (M82: 3569 bp- 4 genes. , 26nm ->1000nm) !
-> large (P ox: 180-200,000 bp-400nm) !
-> huge (pandora, Mimivirus have genome to 1million to 2 million base pair : 2um->5um)!
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Structure:
Basic -> Nucleic acid genome -> wrapped in protein coat (capsid), attachment factors !
Simplest virus structurally are helical viruses -> Tobacco mosaic virus !
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These genome would be infectious !
To the cell !
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Helical virus:
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Document Summary
Virus" natural reservoirs are from birds, pigs, ducks. Virus starts out in extracellular form : virions bind to host cell and get its genome into the host. The host cell is then infected and new particles are being made from the genetic material from the original infecting virus. Virus replicates and release by lysis of host cell. A lot of variety in what type of genome they have. > huge (pandora, mimivirus have genome to 1million to 2 million base pair : 2um->5um) Basic -> nucleic acid genome -> wrapped in protein coat (capsid), attachment factors. Simplest virus structurally are helical viruses -> tobacco mosaic virus. Most virus with capsid is icosohedran (kinda similar to a soccer ball patch) \ 20 faces -> hexagon + pentagons -> each face >= proteins: smallest icosohedral virus has 60 proteins in its shell. complex virus) icosahedral head, helical neck and base plate with attached brous leg (t4 for attachment)
