MCB 2210 Lecture Notes - Lecture 26: Inside Out Music, Myosin, Hemidesmosome
2 Dec 2016
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Document Summary
Cell movement: the stable attachment of cells to the ecm often occurs through hemi-desmosomes (in epithelial cells) and focal adhesions (in non epithelia cells, focal adhesions: macromolecular complexes through which mechanical force and regulatory signals are transmitted. Integrins: are the most prominent adhesion receptors within focal adhesions: focal adhesion integrins: mediate a linkage between fibronectin and the ecm and the intracellular actin cytoskeleton. Integrins and focal adhesions have been well-studies in fibroblast cells. Humans encode ~18 alpha and ~8 beta subunits. Integrin heterodimers interact with multiple ligands, including fibronectin to play key roles in signaling, morphogenesis, and movement in diverse cell types. Integrins provide a physical link between the ecm and actin filaments. Integrin association with actin occurs through actin binding proteins such as talin and viniculin. Many stress fibers are anchored to focal adhesions. Ecm protein (e. g. fibronectin) attaches to active integrin which attaches to abps (e. g. viniculin & talin) which are attached to actin filaments.
