MCB 2400 Lecture Notes - Lecture 4: Histone Deacetylase, Chromatin Remodeling, Hbb
14 Dec 2016
School
Department
Course
Professor
Document Summary
Differential gene expression: turn on/off particular genes. Regulation of gene expression is essential to provide organisms with the necessary proteins required to carry out specific tasks. It is the sum of the complex mechanisms that allow each cell to selectively express the genes that are required to carry out the specific role for that cell and also to respond to changes in the environment. Example: globin chain switching: structure of hemoglobin. Developmental patterns of globin gene expression: hemoglobin synthesis begins in the first few weeks of embryonic development, shortly before birth there is a smooth switch from fetal gamma globin gene expression to adult beta globin gene expression. Globin chains are expressed from alpha globin and beta globin gene clusters: chromosome 11 and chromosome 16 (two different alpha forms: regulatory sequences. Why do we need different hemoglobin molecules: fetal placenta: gas exchange occurs in maternal blood pools between developing fetus and mother.
