MCB 4211 Lecture Notes - Lecture 8: Cell-Mediated Immunity, Colony-Stimulating Factor, Il-2 Receptor
21 Sep 2016
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Document Summary
Hyper sensitivities- normal immune responses with no beneficial effect. Cell mediated immunity: same cell mediated immunity abnormal in certain forms of autoimmune disease against own tissues. Soluble mediators of immunity: cytokines- soluble products of one cell that communicate to change the behavior of producing cell (autocrine), nearby (paracrine), or distant (endocrine, very specific interactions between signal and receptor molecule. Can be redundant- multiple cytokines can stimulate proliferation, can both can stimulate proliferation in same cell or different cell types. Th1 vs. th2: both cd4 positive cells, differentiate in what cytokines they make, th1 gamma interferon. Th1"s help macrophages- participate in cytotoxic t cell activity and dth: th2- il3 il4 il5. Th2"s much better in helping b cells to make antibody: th1 response blocks subsequent th2 response & vice versa. Immune response weighted toward cytotoxic t cell or immunoglobulin response as a result: receptors themselves belong to 5 different families.
