MCB 4211 Lecture Notes - Lecture 3: Xenotransplantation, Immunogen, Antigen
Document Summary
Alleles: could be lethal unless another form of that gene on another one that balances it out. Unlinked genetic material reduced by half every generation. Get smaller and smaller regions of passenger loci. Chimeric mice: two embryos of two different genetically different mice and fused them together, eliminated immune response replaced with another mice"s immune response. Disadvantage to homozygosity: shorter life span, resist disease less, smaller litters, fertility less, reverse of hybrid vigor. Artificial systems: nsg mice - could be a chimeric where human immune cells are transplanted into mice. Cd34: a surface molecule expressed on homatopetic stems cells, common source is umbilical chord blood. Antigen (signal molecule: drive adaptive immunity, molecule recognized by an antigen specific receptors. Immunogen: molecule that stimulates production of t cell receptor and or b cell receptor, most immunogens are also antigens, sizes less than 10 kd is not immunogenic (stimulates an immune response, complexity.