MCB 4211 Lecture Notes - Lecture 3: Membrane Transport Protein, Epitope, Foreign Body
6 Sep 2016
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Allografts: relationships between members of same species. Landsteiner: identified abo blood groups, identified chemical basis of antigenicity, when you mix antibody and antigen together, immune complex is formed, antibodies cross link, aggregation. Found out about visible precipitation- too big fall out of solution (antigen binding sites show bilateral symmetry: took antigens combined with different antibodies. Made antisera from rabbit- liquid fraction of blood after immunization. Made antiserum to one of these antigens (coupled to carrier protein) Antiserum with cognate antigen- antigen designed to recognize foreign body: haptems. Molecules that modify carrier proteins: epitope. Antigenic determinant molecular shape that antibody actually binds to. Multiple antigenic determinant per protein that allow cross linking. Peter gore: build on lansteiner"s studies with george snell. Ted boyse: defined genetic structure of the mhc (major histocompatibility complex, in mhc there is set of genes that is responsible for mating preference in mice.
