NURS 3110 Lecture Notes - Lecture 14: Headache, Blastomycosis, Histamine
Document Summary
How drugs and biologics act on the human body. It includes kinetics (absorption, distribution, metabolism and elimination) and dynamics (how the drug binds to cause an action) Researchers look for drugs and biologics that have little, if any, impact of drugs on human cells. Example: antifungal amphotericin b binds to ergosterol in cell membrane. Human cells use cholesterol (not ergosterol) so there is reduced risk of harm to human cells. Drugs have specific moas, and we cannot make a cell do something out of the ordinary. For example, we can"t take a drug that binds to receptors in the lungs and make those cells control heart rate. Drugs interfere with cellular metabolism, reproduction or growth. Metabolism: is chemical alteration of a substance. You take a drug and eventually you must eliminate it. Cytochrome p450 system family of enzymes that metabolizes some drugs. Some drugs are inhibitors while other induce and other do both!
