NURS 3110 Lecture Notes - Lecture 20: Rimantadine, Amantadine, Tuberculosis
Document Summary
Penetration to site of infection: ma(cid:374)(cid:455) (cid:272)a(cid:374)"t pe(cid:374)etrate (cid:373)e(cid:374)i(cid:374)ges (cid:894)bbb(cid:895, uti requires agent to accumulate in urine. Low in bone (treat for 4-6 weeks in osteomyelitis) Low in skin abscesses, areas poor blood flow. Patie(cid:374)t"s i(cid:373)(cid:373)u(cid:374)e tatus: neutropenia decreases ability to fight infection. Immunocompromised need bacterial prophylaxis: think: patients with hiv/aids, cancer and its treatments, long-term corticosteroids, the frail elderly, patients with chronic disease, transplant patients, some pregnant women. Inhibition cell wall synthesis (cidal: alteration of cell membranes (cidal, antimetabolic activity (static) Inhibition of nucleic acid synthesis (cidal, but may be static in aids) Potency must also be considered against the pill burden, dosing schedule, and food and fluid restrictions that may be required for some agents. Some of these restrictions may be especially difficult for patients to observe: other important considerations include potential drug interactions with other agents and comorbid conditions such as hepatitis b or c, renal or hepatic insufficiency, and diabetes.
