EEMB 50 Lecture Notes - Lecture 7: Leonard Hayflick, Telomere, Cell Culture
19 Apr 2017
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Demonstrated that a population of normal human fetal cells in a cell culture will divide between 40 and 60 times. Telomeres shorten at every division and lead to programmed senescence" acting as a powerful check on cancer. Small bits of the ends of the chromosomes fall off after each replication, but they aren"t vital. Many cancer cells produce telomerase which prevents telomere from shortening. When the tumors grow large, the blood vessels do not form where it is need, therefore the tissue dies. Then the dead tissue would cause infection to spread. The cancer can grow so large that there are not enough normal cells, for example in the liver, to be able to function correctly. Ability of an organism to maintain internal equilibrium by adjusting its physiological processes. Bone cancer can lead to the release of large amounts of calcium in the blood.
