MCDB 153 Lecture Notes - Lecture 4: Blastula, Neurulation, Gastrulation
9 Dec 2017
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If allow interaction with mesoderm-> become neural tissue. Noggin: produce large head when expressed in high level. Focusing on receptors: 3 classes of ligand-activated cell surface receptors a. b. c. Activin (one of the ligand) binds to one of the receptor. Blocking signaling via a dominant negative activin receptor lead to neutralization. Activin or some other related ligand normally inhibit neuralization. Inhibit epidermalization factor -> get back to the default mode (neural) Dissociation of animal cap cells prior to gastrulation causes them to differentiate into neurons in culture. Suggest by diluting the epidermalization factor-> get neural. So neural, not epidermal, is the default fate of the ecotoderm. Neural is the default fate for ectodermal cells. Some activin related signaling pathway induces ectodermal cells to become epidermal. The mesoderm secretes some unidentified factor that inhibits the activin related signal, suppressing the activin related signal"s epidermalization activity, leading to the default neural fate.
