BIPN 100 Lecture Notes - Lecture 3: Resting Potential, Integrin, Giant Cell

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Inside cell: high concentration of potassium (k+) Outside cell: high concentration of na+ and cl- If the cell is at -70mv: k+ will move out so the cell will become more negative so that it will reach -90mv. Membrane with no channels: not permeable to ions, permeability of an ion is greatest for k, vm changes when the channel opens: ions will flow in a certain direction, in order to bring the vm towards its eion. Polarize: make it more negative, must know resting membrane potential, and the equilibrium potential. Signaling: think about spheres of influence extremely locally or intermediate distances or long distances. Local communication: direct chemical and electrical coupling between cells, both cells express half of the channel, cytoplasmic connectivity (as local as you can get with signaling, homo or heteromeric channels, varied selectivity, water filled. Iii: generally immune, inflammation, stress responses, generally act locally, diffusion, made on demand.

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