BIPN 150 Lecture Notes - Lecture 11: Pervasive Developmental Disorder, Intellectual Disability, Audism
Document Summary
Lecture 11, older diagnostic categories (now all are included in the general diagnosis of asd, asperger"s - mild end of spectrum, may be very intelligent, but difficult to socialize. Usually also develop a seizure disorder: asd may be present in certain genetic syndromes, not all individuals with the syndrome show asd (20-70%, depending on which syndrome, tuberous sclerosis complex (tsc) Fragile x syndrome: rett syndrome, timothy syndrome, these genetic syndrome-associated asd only account for 5-10% of all cases of asd the rest are sporadic or non-syndromic, syndrome-associated forms of asd contribute to our understanding of the asd. Pathogenesis: example: fragile x syndrome, most common hereditary cause of intellectual disability and audism, affects 1:5000 births. Fragile x syndrome (mouse & human) shows increased density of dendritic spines and elongated shape - glutamate: mglur-dependent ltd is normally dependent on early protein synthesis.
