BIMM 120 Lecture Notes - Lecture 13: Non-Alcoholic Fatty Liver Disease, Human Microbiome Project, Inflammatory Bowel Disease
26 Dec 2018
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Guest lecture: pay attention to the following: fecal transplantation to cure infections caused by c. difficile, microbiome at birth. Overview of gut microbiome: humans made up of 30 trillion human cells and 39 trillion microbial cells, 43% human cells, 1% human genes. Microbes can affect methylation markers and histone acetylation markers, which affect expression of dna. If you have 2 unrelated communities: if one species moves to the other community, can"t survive and reproduce: exploit"s darwin"s insight that there is one common tree of life, different parts of the body have different microbes. Why you care about gut microbiome: c. difficile: most common hospital-acquired infection, causing diarrhea, kills 14,000-17,000 people a year. Usually triggered by clindamycin: fecal samples of patients with this infection have microbes that are not like microbes of healthy person, fmt: fecal microbiota transplant, get fecal microbes from healthy donor. Immediately, patient"s microbiome transform into healthy state, and stays healthy in just 2 days.
