PSYC 181 Lecture Notes - Lecture 6: Synaptic Vesicle, Dendrite, Synapsin
Document Summary
Dendrites and spines: spines can build in 15 mins, dendrites can be built in 2-3 hours, everything very dynamic. Multiple types of synapses: vesicle varieties: vesicle = where transmitter stored, different vesicles have different transmitter and you can tell by shape, spherical agranular vesicles, spherical granular, reciprocal junction, flattened vesicles. Multiple types of synapses: multiple patterns of connectivity: axodendritic: majority 55, dendrodendritic, axoaxonic, axosomatic, etc. Inactivation: reuptake: taken back in, transporters: big site for drugs bc if targets transporter you prevent reuptake and cause buildup of transmitters, enzymatic degradation, metabolism, excretion, cycling. Receptors: molecule that drug or transmitter is going to interact with, typically on postsynaptic side or attached to cell membrane, could be anywhere though, classification: by location, postsynaptic, autoreceptors. Receptors: classification: by transduction mechanism, drug, transmitter or hormone binds to receptor, transduction process turns this into intracellular signal -> dramatically magnifies effect of drug.
