ANFS332 Lecture Notes - Lecture 13: Filoviridae, Herpesviridae, Immunoperoxidase
4 Feb 2020
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Document Summary
Alter cellular metabolism so that viruses are produced. Genetic material is often accompanied by viral proteins. Initiation (attachment and eclipse) the virus attaches to cells, penetrates cells, and is disassembled and no new progeny have been formed. Maturation (assembly and replication) virus particles are produced and accumulate exponentially. Viral production ceases when all the cells die. Entry into permissive cells followed by a productive infection. Entry into a non-permissive cell which does not result in a productive infection. Transiently permissive and a few virus particles are produced. This can result in cell transformation and cancer. Presence of virus in the blood (bacteremia?) Polio virus is an example of a virus that spreads via the blood. Cells (and tissues) can respond to viral infection in three ways. Apoptosis: histopathology involves the microscopic examination of cells and tissues. Altered shape/lysis: human rhinovirus on human fibroblasts (105 serotypes) Viral replication remains localized near site of infection (skin, respiratory, gastro-intestinal: disseminated (systemic)
