ANFS332 Lecture Notes - Lecture 20: Antibody Titer, Clonal Selection, Titer

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Immunology iv clonal selection hypothesis, antibody structure, antibody diversity, In this figure, an animal was injected with antigen a at day 0. Antigen a invokes a primary response beginning about day 4,as indicated by a rise in the specific antibody titer. Titer = a measure of the amount of antibody in the animal"s serum per unit volume. A peak titer occurs between days7 and 10, then the response decreases rapidly. If the animal is reinjected withantigen a at day 28, the production of antibody begins almost immediately and reaches a level 1000- fold greater than that seen in the primary response. This is known as the secondary response and the principal antibody produced is igg. Consider a second antigen(antigen b) which is administered at the same time as the reinjection of antigen a. Only a primary response toantigen b is observed. The clonal selection hypothesis (jerne and burnet) Animals contain lots and lots of lymphocytes.

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