ANFS332 Lecture Notes - Lecture 8: Rebecca Lancefield, Rheumatic Fever, Streptokinase
27 Nov 2016
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Document Summary
Chronic inflammation: a pathological condition, chronically inflamed tissue is characterized by the infiltration of macrophages, tissue destruction, and repeated attempts at healing. In chronically inflamed tissue, the stimulus is persistent, and therefore recruitment continues, existing macrophages are tethered in place, and the proliferation of macrophages is stimulated. The anti-inflammatory program ends with the departure of macrophages. Mechanisms of pathogenicity: how does streptococcus equis cause the disease, many virulence factors, nonantigenic hyaluronic capsule. Capsule inhibits the activity of neutrophils and is required for function of. Binds to erythrocytes and forms a transmembrane pore resulting in lysis of the cell. Destroys cell membrane and lyses them: pyrogenic toxins-spe. Molecules that non-specifically stimulate immune cells to release pro- inflammatory cytokines resulting in an uncontrolled acute inflammatory response. Called pyrogenic exotoxins (spe) or superantigenic toxins (does toxic shock sound familiar?: streptococcal m protein- sem. Found on fibers on the bacterial cell surface.
