BISC401 Lecture Notes - Lecture 15: Amphiphile, Sec61, Amine

• School: University of Delaware
• Department: Biological Sciences
• Course: BISC401
• Professor: Dr.Salil Lachke

Document Summary

Polyade(cid:374)ylatio(cid:374) at the 3" utr of (cid:373)rna ca(cid:374) regulate tra(cid:374)slatio(cid:374) In immature oocytes, mrnas containing the u-rich cytoplasmic polyadenylation element (cpe) have short poly (a) tails: cpe-binding protein (cpeb) bound to the u-rich cpe interacts with the protein. Maskin, which in turn bonds to the eif4e associated with the (cid:373)rna 5" cap: as a result, eif4e cannot interact with the other initiator factors or the small ribosomal subunit, so translation initiation is blocked. Translationally active: hormone stimulation of oocytes activates a protein kinase that phosphorylates. Prokaryotic mrnas are polycistronic because ribosomes can bind internally to initiate translation. Proteins are made on the er or in cytosol and then transported to various places in the cell. Targeting sequences direct proteins to the proper site. Synthesis of secreted proteins, integral plasma-membrane proteins, and proteins destined for the er, golgi complex, plasma membrane, or lysosome begins on cytosolic ribosomes. All eukaryotic cells have an endoplasmic reticulum (er)