BISC403 Lecture Notes - Lecture 16: P21, Nuclear Membrane, Mitosis
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Lecture xvi the genetics of cancer part 2. 19. 2 the genetic basis of cancers: what is the model/how does it happen, is it a genetic disease. Cancer is generally a disease of old age. Example of ec signal that acts over large distances: tsh produced in pituitary gland, moves through blood to thyroid gland, which expresses thyroxine. Signal transducers relay the signal inside the cell: get growth signal then transcription and translation to get protein that stimulates cell division, transitioning into different phases is due to cell signaling. Ras-mediated signal transduction: gtp bound, ras active, cell proliferation. Because cyclins bind and interact with cdks, they regulate the cell"s progression through the stages of the cell cycle: cyclins activate the cdks; the cdks then act. Cdks interact with cyclins and control the cell cycle by phosphorylating other proteins: cdks family of kinases that regulate the transition from g1 to s and from g2 to.