KAAP221 Lecture Notes - Lecture 12: Natural Killer Cell, Innate Immune System, Endothelium

• School: University of Delaware
• Department: Kinesiology & Appl Physiology
• Course: KAAP221
• Professor: Shannon Lennon

Document Summary

Lecture 12: immunity, ability to fight infection, illness, and disease, two complementary mechanisms work independently and together - innate and adaptive systems, 1. Innate (nonspecific) immunity: adaptive (specific) immunity - utilizes adaptive defenses; protects against particular threats; depends on activities of specific lymphocytes; produces state of protection known as specific resistance. Doesn"t distinguish one type of threat from another. Response same regardless of type of invading agent. Found along digestive, respiratory, urinary, and reproductive tracts. Presence of unusual pm activates nk cell; nk cell adheres to target cell (come into contact) Golgi apparatus of the nk cell moves within nk cell near target cell and produces many secretory vesicles containing perforins. Perforins released from nk cell and arrive at target cell. Performs create pores in target cell membrane - target cell can no longer maintain its internal environment and disintegrates: mistakes in cell division. Proteins interact with one another in chain reactions or cascades (similar to blood clotting system)