KAAP430 Lecture Notes - Lecture 2: Glycogenesis, Biopsy, Carbohydrate
20 Dec 2016
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Chapter 1; structure and function of exercising muscle. Cardiac muscle & skeletal muscle have striations (actin and myosin contraction) T tubules take action potential down into the cell. Sarcoplasmic reticulum contains calcium (important for muscle contraction) At rest, tropomyosin is covering binding sites for myosin heads on the actin, calcium binds to troponin and releases tropomyosin. **know what troponin, titin, actin, myosin etc. do. Runs through myosin filament, anchors it at center of sarcomere. Extensible portion allow titin to stretch & increase force (eccentric contraction), prevents overstretch. Anchors myosin, prevents overstretch, helps increase force. Neuromuscular junction= connection between end of motor neuron and muscle fiber itself. Go from excitation of muscle fiber to coupling. Myosin heads grab actin filament and pulls it toward center line, more overlap of actin and myosin (h zone shrinks) Need atp to detach actin and myosin. Causes release of actin and myosin head and the power stroke (when actin is pulled towards center line)
