PSYC314 Lecture Notes - Lecture 1: Therapeutic Index, Neurotransmitter Receptor, Agonist
21 Aug 2018
School
Department
Course
Professor
Document Summary
Changes drug produces in an animal"s physiological processes and behavior . Site of action: cells of body, thus affecting some biochemical processes of these cells. Movements of drugs, including process by which drugs are: Absorption: drug is administered and absorbed through tissue. Distribution: drug travels throughout the body and blood stream. Metabolized: drug is changed to an inactive form (usually by the liver enzymes) Intracerebroventricular (icv) (into ventricles: quick peripheral routes. 1: subcutaneous (sc) injection , oral administration , sublingual administration . 5: topical administration, slower peripheral routes . Dose-response curve graph of magnitude of effect of drug as function of the amount of drug administered . Ratio between dose that produces desired effect in 50% of animals and dose that produces toxic effects in 50% of animals. 12mg/kg produces the desired effects in 50% Why do drugs vary in their effectiveness? . Affinity:readiness with which two molecules join together . Facilitate or inhibit postsynaptic receptor activity .
