APK 2105C Lecture Notes - Lecture 34: Smooth Muscle Tissue, Hyperaemia, Capillary Pressure
16 Jun 2018
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Chapter 14, Lecture 5
Vessels & Blood Pressure
• Types of intrinsic regulation of organ CO
o Changes in vessel diameter = dictates vessel resistance
▪ Smooth muscle relaxation vs. contraction
▪ What signals the smooth muscle?
• Metabolic activity (active hyperemia)
o Activity of cells
o Body’s ability to communicate to blood vessels to get more
blood to the organs
o CO2 goes from cell to ICF to capillaries to be carried away
o Delivery of O matches
rate of O consumption
o Matching of metabolic
need to reactive = no
significant changes in
CO2 and O levels in ICF
o When you increase
metabolic rate, consume
O faster than blood
supplies, give off CO2
faster than can be taken
away = higher CO2
concentration =
vasodilation of arteriole =
lower resistance = more
blood = increased O
supply = increased taking
CO2 away
• Changes in flow (reactive
hyperemia)
o Low BF
o Low O concentration,
increased CO2 con
o Vasodilation
o Low resistance
o More BF
o More O delivery, more CO removal
o Often caused by blockage
• Muscle stretch (myogenic response)
o Increased perfusion pressure (more
BF to organ)
o Increased BF
o Increased stretch of arteriole
o Constriction
o More resistance
o Loess flow
o Negative feedback to get back to
where they were
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