APK 2105C Lecture Notes - Lecture 39: Intrapleural Pressure, Transpulmonary Pressure

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Chapter 14, Lecture 3
Pulmonary Ventilation
Mechanics of breathing
o Flow = pressure gradient / resistance
o Air flow = Patm Palv / resistance
Because Patm is constant, changes in Palv determine the direction of air
Palv < Patm = air into lungs
Palv > Patm = air out of lungs
o Determinants of Palv
Alveolar volume (size)
Changes in volume of alveoli are produced by changes in volume
of TC
o Boyle’s law
o Increase
volume of
TC = pull
open lungs =
o Decrease
volume of
TC = close
lungs a little
Respiratory muscles
expand of compress
the TC
Thoracic volume
impacts alveolar volume
o Diaphragm contracts, goes down = inspiration
o Diaphragm relaxes, goes back up = expiration
Quantity of air molecules in alveoli
Breath volume increases =
Neural control of ventilation
o Motor neurons signal neural input
o Inspiratory muscles get signal and contract
o Chest wall expands and causes intrapleural
fluid to get pulledincreased volume in
intrapleural cavity
o Increase in transpulmonary pressure
o Increased alveoli volume, flow of air into
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