BCH 4024 Lecture Notes - Lecture 43: Dna Polymerase I, Dna Clamp, Dna Ligase
27 Nov 2017
School
Department
Course
Professor
Document Summary
Key concept: prior to division a cell must duplicate its entire genomic dna in a process called replication. Each daughter cell inherits a complete complement of the genetic information. Blue: key terms; should have thorough understanding of these concepts. Can also test on anything said in lecture. You should know: modern central dogma, mechanism of dna polymerase, semiconservative replication, bidirectional synthesis, replication fork, leading and lagging strands, topoisomerases, replication in prokaryotes, dna polymerase iii, oric and replication initiation, primase, replication elongation, replication termination. Lectures l-43 and l-44 in lehninger 7th ed. Dna used as template to synthsize more dna. 4 genomes with two complete sets of genes in every cell. every cell has same sequence throughout the body. - at 3. 4 /bp a human cell contains ~2 m of dna! all fits in nucleus (6 microns in diameter) Key concept: dna polymerase catalyzes the extension of a dna strand only in the 5" 3" direction.
