BSC 2011 Lecture Notes - Lecture 18: Cell Membrane, Clonal Deletion, Clonal Selection
24 Aug 2016
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Document Summary
Innate (non-specific: acquired at birth, first (skin, mucous membranes, secretions) and second (phagocytes, antimicrobial proteins, natural killer cells, the anti-inflammatory response, and fever) line of defense, all animals. Acquired/adaptive (specific: humoral response b cells and antibodies fighting off infections, cell-mediated response cytotoxic t-cells defending against infection, only vertebrates. Some ducts secrete lysozyme, which breaks down cells walls. Depends on phagocytosis kill bacteria that get trapped in mucous membranes. Natural killer cells kill cells infected with virus or cancer. Identify cells with mhc or no mhc release enzymes kills cell. Basophils = inflammatory response release histamine and promote development of t cells. Eosinophils protect against allergens and parasitic infections. Mast cells = inflammatory response histamine. Monocytes phagocytic cells macrophages and dendritic cells. Helper t cells recruit other cells. Cytotoxic t cells (killer t cells) attack invaders. Natural killer cells distinguish between healthy and infected cells. Distinguished through antigens class i mhc protein.
