ADSC 4300 Lecture Notes - Lecture 9: Mesenchymal Stem Cell, Lateral Plate Mesoderm, Endochondral Ossification

• School: University of Georgia
• Department: Animal and Dairy Sciences
• Course: ADSC 4300
• Professor: Liu

Document Summary

Involves up-regulation of numerous growth & signaling factors: mesenchymal cells become dense, very tightly organized (aka condensation, they then further differentiate, molecular control of osteogenesis, runx2 & osterix are essential for bone formation & osteoblast development. Mesenchymal cells osteoprogenitor pre-osteoblast mature osteoblast. Important factors for adipose tissue formation: pbrgamma (master regulator) 6: osteocytes (mature cells in bone, osteoclasts, chondrocytes, chondroblasts, osteoblasts, osteoprogeneitor cells, from mesenchymal stem cells, they become committed, these cells undergo hypertrophy & differentiation & become osteoblasts. Bone formation types: endochondral ossification: requires a cartilage template, endochondral (cartilage) growth: long bone development, always see cartilage growth first. Then you see bone growth in the central region: cartilage model enlarges with continued secretion of collagen matrix. Interstitial cartilage growth (within cartilage tissue: appositional cartilage growth (outside cartilage tissue, zone of growth plate from epiphysis to diaphysis, zone of growth, no vascular supply, this zone has stem cells.