CBIO 3400 Lecture Notes - Lecture 33: Integrin, Collagen, Elastin
14 Apr 2016
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*most important function is to form a barrier. Where two cells join each other (important for embryos) Homophilic binding: the same proteins bind to each other (developmental bio) Heterophilic : two different cells that recognize each other and bind together (immune system) A protein will do either one or the other type of binding. Transmembrane proteins that bind to other cadherins of the same type (adhere to each other and are calcium dependent) Bind to each other with low affinity and the interactions can be easily disrupted (think cuts in skin) Having different cells with different levels of cadherin forms different organization of cells (high in (cid:373)iddle with low surrou(cid:374)di(cid:374)g it like a(cid:374) e(cid:373)(cid:271)ryo) Cadherins link to actin which creates to tissue remodeling by recruiting more cadherins to bind to more actins. Cadheri(cid:374)s (cid:271)i(cid:374)di(cid:374)g a(cid:272)ross two (cid:272)ells (cid:272)reates te(cid:374)sio(cid:374) (cid:271)etwee(cid:374) the two (cid:272)ells this te(cid:374)sio(cid:374) (cid:272)aused (cid:271)y a(cid:272)ti(cid:374) pulling away the cadherin, trying to break the bond.
