CBIO 3400 Lecture Notes - Lecture 32: Myf5, Myod, Myogenin
15 Apr 2016
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Document Summary
Myotome cells becomes dividing myoblasts which then go through cell alignment. Ater alignment, cells fusion together and mature into myotube which leads to muscle iber. A process by which a cell changes to a specialized cell that is really good at doing one thing. Express speciic genes necessary for funcional specializaion --> oten leads to the formaion of organs. Took stem cells and expressed them to myod they formed muscles cells [myod is suicient, not necessary for forming muscles cells] A study with mice proved suicient, not necessary. Found more factors like myf5, myogenin, and mrf-4 that can form muscles (ie. myf5 takes over in a. Myod mutant, but a myod-myf5 double mutant have muscle defects) These cells are muli nucleated and share many organelles together. (so, one giant cell with many nuclei) This is an example of why it"s good these cells exit the cell cycle. Satellite cells: needed for muscle growth and recovery ater injury.
