POUL 3000 Lecture Notes - Lecture 2: Antibiotics, Histology, Osmotic Concentration

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Hypoxemia (inadequate o2 transport) sensed by liver & kidneys secretion of erythropoietin stimulation of red bone marrow accelerated erythropoiesis increase rbc count increased o2 transport. B12 this will lead to lethargy (can"t oxygenate your blood as well and power your system) Inadequate erythropoiesis or hemoglobin synthesis: traumatic injury, bacterial infection, hypothyroidism. **colloid osmotic pressure: anemia has 3 potential consequences, tissue hypoxia & necrosis, the tissues suffer hypoxia (oxygen deprivation), the individual is lethargic & becomes short of breath upon physical exertion. The skin is pallid because of the deficiency of hemoglobin. Erythropoietin (epo: glycoprotein hormone synthesized in the kidney to stimulate rbc production in bone marrow, hypoxia increased epo secretion, androgens increased epo secretion. Procrit: renal failure, chemotherapy, will target rbc producing cells, hiv patient on azt, blood loss from surgery (recovery, cheating athletes, chimeric chicken that produces human epo*, renal failure would be bad because epo is filtered in the kidneys.

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