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Lecture 17

BIOL 1353 Lecture Notes - Lecture 17: Epitope, B-Cell Receptor, Antigen


Department
Biology
Course Code
BIOL 1353
Professor
Knapp
Lecture
17

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Chapter 17 Adaptive Immunity
Third line of defense
- Specialized lymphocytes: T cells and B cells
- Antibodies
- Antigens (Ag) are molecules, that in the body, activate lymphocytes antigens =
structures on the periphery, can be cell wall, capsule, flagella, proteins on the surface,
etc.
o B cells: interact with antigen via surface immunoglobins, (i.e. antibodies)
o T cells: interact with antigen via surface antigen receptors
- Interaction with antigens occurs with smaller segments called epitopes or antigenic
determinants
o Epitopes that elicit an immune response can be protein, peptide, or complex
polysaccharides
Antibody structure and diversity
- Variable regions of these chains possess variable amino acid sequences and are antigen-
binding sites antigen binds to the variable region, these vary from antibody to antibody.
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