MCB 150 Lecture Notes - Lecture 31: Phenylalanine, Translocon, Missense Mutation

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Published on 10 Apr 2017
School
University of Illinois
Department
Molecular and Cell Biology
Course
MCB 150
Professor
Problem solving for exam 3
Announcements
EXAM
5:00 is the deadline for conflict
Review session 5-7
Office hours noon-2
Wednesday is optional review
Office hours 3-5 wednesday 233 greg
Slido event codes 410
Wednesday 10pm is deadline for answers on forums
Exam thursday 7-9
Friday is a regular class period
Learning catalytics
1. During skeletal muscle contraction, which of the following are changed?
a. Length of the actin filaments
b. Length of the region occupied by only actin
c. Length of the myosin fibers
d. Length of the region occupied by only myosin
e. Length of the sarcomere
2. You are studying the synthesis and localization of a protein with an amino
terminal signal sequence, a stop transfer sequence, an internal signal sequence,
and another stop transfer sequence. You have traced this protein to the rough
ER, and see that its amino terminal signal sequence is in the process of being
inserted into a translocon. At this instant, you add a drug that immediately
inactivates SRP and investigate the possible effects. Which one of the following
most likely represents the orientation of this protein following translation, while it
is still associated with the endoplasmic reticulum?
a. How to think about the problem:
a.i. How does SRP act?
a.i.1. Brings the peptide to ER
a.ii. What is the timing of the drug?
a.ii.1. SRP has already gotten the peptide to the ER
a.ii.2. We can assume that the protein is already in the
translocon and is still being translated
a.ii.3. N terminus is in the lumen
a.ii.4. Nothing else has been affected, so the amino terminal
sequence will still get chopped off
a.ii.5. The next step is the stop transfer sequence.
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Document Summary

Wednesday 10pm is deadline for answers on forums. You have traced this protein to the rough. Er, and see that its amino terminal signal sequence is in the process of being inserted into a translocon. At this instant, you add a drug that immediately inactivates srp and investigate the possible effects. Which one of the following most likely represents the orientation of this protein following translation, while it is still associated with the endoplasmic reticulum: how to think about the problem: a. i. What is the timing of the drug? a. ii. 1. a. ii. 2. Srp has already gotten the peptide to the er. We can assume that the protein is already in the translocon and is still being translated a. ii. 3. a. ii. 4. Nothing else has been affected, so the amino terminal sequence will still get chopped off a. ii. 5. The next step is the stop transfer sequence. a. ii. 5. a. The drug does not affect the stop transfer sequence a. ii. 5. b.

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