MCB 250 Lecture Notes - Lecture 9: Histone H1, Type Ii Topoisomerase, Type I Topoisomerase
12 Oct 2016
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Document Summary
1953 the working hypothesis was adopted that chromosomal dna functions as the template for. In 1953 francis crick referred to this pathway for the flow of genetic information as the central. Dogma: duplication dna transcription -> rna translation -> protein. Rna chains sometimes act as templates for dna chains of complementary sequences although this is very rare. Crick proposed that amino acids are first attached to specific adaptor molecules, which then posses unique surfaces and can bind specifically to bases on the rna templates. In 1953 paul c zamecnik radioactively tagged amino acids, which were used to track new proteins: early on, the cellular site for protein synthesis was pinpointed to be the ribosome. Each trna contains a sequence of adjacent bases called anticodons that bind specifically during protein synthesis to successive groups of bases (codons) along the rna template. ~85% of rna is found in ribosomes.
