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Lecture 1

MCB 252 Lecture Notes - Lecture 1: Major Force, Apoptosis, Gene Duplication

Molecular and Cell Biology
Course Code
MCB 252
Rivier David

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MCB 252
Lecture no. 1
- After lecture questions Questions due Friday at 9 am and Homework assignment.
Everything is on loncappa
- You can re-watch the videos
- 977-979 pg to read
- Steve Elledge
- Elaine Fuchs skin stem cells
- Mark Krasnow organ development
- Edwin Krebs Phosphorylation
- Susan Lindquist
- Doug Melton
- Jim Spudich
- Jamie Thomson
- All of these people were undergrads at UIUC.
o What we know how we know what we know Asking new questions seeking
answers making new hypotheses and testing them.
Gene Expression v. Transcription
- Every step in a biological process is a potential site of regulation. (biological decision making)
- EVERY step is a possibility of regulation which means gene expression
- Most common regulation is transcriptional because it is energetically efficient.
o Protein activity control is second because it is the fastest.
- ~210 different types of cells (10^14 cells)
- Each cell type has its OWN pattern of gene expression.
- Stem cells replenish all the other cells in the tissue. They can become differentiated and
specialized. This is called terminally differentiated. these cells typically don’t divide
o One of the 2 daughter cells stays a stem cell asymmetric division.
- Pluripotent means they can give rise to any type of cell
- Signal transduction is the way that cells talk to each other. Cells release signals, which are picked
up by other cells. (Ligands, peptides, proteins, amino acids)
o The receiving cell has a receptor.
Which means you will have trans membrane proteins.
- Coordinating multiple responses to a single signal.
o Sometimes the effector proteins can get turned on/off
- Hydrophobic can get across the membrane they can directly get into the nucleus.
01/20/ 2017
- Signal transduction pathways Described by the type of receptor that they have.
o There are nuclear receptors or hormone receptors and cell surface receptors
o Ion- channel couples receptors: there are energy dependent and energy independent types
of ion channel receptors.
- 4 possible types of responses survive. growth and divide. differentiate. die or
o There is logic behind this. Skin cells connect with skin cells.
Growth factors, mitogens, cytokines
- There can be apoptosis during development. (Webbing in frogs is an example)
- Apoptosis can also happen with DNA damage.
o Low damage DNA will turn on DNA repair mechanism.
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