BIOS 350 Lecture Notes - Lecture 3: Human Behavior, Multiple Organ Dysfunction Syndrome, Zoonosis
Document Summary
Emerging disease: a disease that has either not been present or has not been present at rate currently before in history. Filovirus: enveloped nonsegmented negative stranded rna virus. Severe, >20 previou ebola and marburg virus outbreak. Transmission- zoonotic virus (bats reservoir), human-human, contact with body fluids. Early clinical presentation- acute (8-10 days, 2-21 range) fever, myalgias, anorexia. Nonspecific hypovolemic shock and multi-organ failure, hemorrhagic disease, death. Non fatal improve 6-11 days fatality rates of 70% in rural africa. Virus closely related to those previously infected humans. Liberia, sierra leone, guinea(sl got it the worst) 60% of all caes linked to traditional burial practices. Jfk med center in monrovia(damaged by civil war and infrastructure) 1 case->traditional healer->attracts more cases->healer dies-> funeral linked to 365 new cases. Patients who survive have antibodies 2 weeks after illness. Prolonged convalescence- fatigue, anorexia etc 21 months out.