BIOS 222 Lecture Notes - Lecture 1: Tumor Suppressor Gene, Innate Immune System, Immunotherapy
Document Summary
Innate immune system and its role in cancer. Recommended reading - biology of cancer by robert weinberg. The emperor of all maladies - dr. mukerjee. Fibroblast- is a type of cell that synthesizes the extracellular matrix and collagen. Hodgkin"s lymphoma - hodgkin disease is a type of lymphoma, a cancer that starts in white blood cells called lymphocytes. Lymphocytes are part of the body"s immune system. Tumor cells probably cannot grow without other human cells. Basophil- (least common 1% of wbc) contain anticoagulant heparin and prevents blood from clotting and it also has heparin to allow blood flow. Dendritic cells - has many subtypes, macrophages (most investigated). Pathway) pathway to promote dendritic cell activation to fight t-cell immunity. Timeline of cancer = surgery (1850), radiotherapy (1900), chemotherapy (1950), Immunotherapy only works in a fraction of patients. More macrophages the patients tend to do worse in getting better from cancer.
