BIOS 222 Lecture Notes - Lecture 19: Tumor Suppressor Gene, Cell Cycle Checkpoint, Anaplasia
Document Summary
The targeted way to fig out what causes cancer came out of sequencing particular parts of genome to find out what genes had the most mutations in them. All start with extracell sig proided by neighboring cell like a growth factor in case of the map kinases sometimes, mitogen. In cell cycle chapter, based in chapter 18, we talked about lack of repairs so there"s 2 things that happen in cancer, mutation that causes promotion of the cell cycle. Theres also damage to proteins that prevent cell from cycling and good example of those kind of proteins which are tumor suppressor genes such as p53. A lot of proteins involved with supporting p53"s, fucnts such as p21. Intro statement slide 2 main classes of genes: proto-oncogenes and tumor suppressor genes. Oncogenes don"t exist in genome, it"s the precursor type. They"re normal genes, but if mutated, promote cancer formation.
