BIOS 286 Lecture Notes - Lecture 4: Axon Terminal, Aroma Compound, Olfactory Bulb
Document Summary
Neurons expressing the i7 olfactory receptors respond selectively to aldehydes based on the length of their carbon backbone. Glomerular organization: 2000 glomeruli; 25 mitral cells per glomerulus. Olfactory receptors are mapped to individual glomeruli in the olfactory bulb. Osns with the same color express the same or protein; osns with different colors express different or proteins. Osns expressing the same or are distributed randomly throughout epithelium. Each glomerulus receives input from osns expressing the same or. The mapping is hard-wired (stereotypic) for a species. Expression of or gene not induced by the bulb; look early in development, osn starts to express or before sending out its axon. Not dependent on neural activity; normal in cng ko mouse. Expose mice to different odors and determine what cells become active. Use metabolic mapping: radioactive 2-deoxyglucose is taken up by active cells using lots of glucose. Each odor produces a distinct pattern of glomerular activation (most activate several glomeruli)
