KN 252 Lecture Notes - Lecture 4: Mean Arterial Pressure, Blood Vessel, Cardiac Output

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15 May 2017
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Circulatory physiology blood flow from the heart to the heart. This is driven by a drop in pressure from beginning to end of the circulatory pathway: compliance affects bp stretchability of the artery; more compliance, less pressure build up, cardiac cycle affects bp. Diastole pressure maintained during relaxation: location (in vascular system) affects bp. Arteries = highest pressure (average bp of large artery ~ 93. 3 mmhg) Capillaries = enter bed at ~ 40 mmhg (leave at ~ 20mmhg) Veins = enter at ~ 20 mmhg (leave at ~ 0 mmhg at vena cava: flow (volume of flow) same as cardiac output (hr x sv, venous return (influences cardiac output) Muscle pump (influences venous return) positive pressure. Respiratory pump (influences venous return) sucking in blood to thorax: resistance retarding factor; affected by the following: Mean arterial pressure = diastolic pressure + pulse pressure/3. Pulse pressure = systolic diastolic pressure: viscosity thickness of blood (hematocrit); thicker blood, greater resistance.

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