BIOLOGY 305 Lecture Notes - Lecture 7: Centromere, Ascus, Vulgate
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4: 12, 14-15, 17-25, 27, 29-33, 35-36, 38-52. But . recombination hotspots & blocks cause deviation from strict proportionality between genetic distance and physical distance: can have multiple recombination events [figure 4-11] [figure 4-10, meiocyte 3] Generally only 2 of 4 chromatids participate in recombination. When multiple strands are involved, 2nd crossovers are as likely to undo the first recombination as add to it [figure 4-19] P = pr vg / pr vg x pr+ vg+ / pr+ vg+ F1 test = pr vg / pr+ vg+ x pr vg / pr vg. 305 of 2839 (10. 7%) are recombinant -> distance is 10. 7 mu results from test cross 2 (wild-type in trans) F1 test = pr+ vg / pr vg+ x pr vg / pr vg. 303 of 2335 (13. 0%) are recombinant -> distance is 13. 0 mu. Both crosses give similar estimates for the distance between these genes.
