BIOLCHEM 415 Lecture Notes - Lecture 34: Tamoxifen, Chromatin, Ribonucleotide

• School: U of M
• Department: Biological Chemistry
• Course: BIOLCHEM 415
• Professor: Raymond Trievel

Document Summary

We will be looking at transcription in eukaryotic cells. In eukaryotic we have 3 different rna polymerases that can recognize different promoter sequences to express different rna molecules in contrast to bacteria where one polymerase did it all. These polymerases are called rna polymerase i, ii, and iii. Rna polymerase ii is a very important polymerase because we will see that it is the polymerase synthesizing the primary rna transcripts that can be modified and converted to messenger rnas. We will look a lot of its regulations and how it"s recruited to promoters through transcription factors. The compaction can inhibit transcription so we have ways we can modify it. A gene is a region of dna that is transcribed to produce a functional rna molecule. That rna molecule can come in two types. It can encode a protein or messenger rna. There are also genes that can encode molecules that are not translated.