BIOLOGY 225 Lecture Notes - Lecture 8: Asthma, Mechanoreceptor, Stimulus Modality

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ochrepug652

28 Sep 2016

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Synaptic transmission : electrical synapse gap junction! Pre-synaptic and post-synaptic neurons are directly connected through gap junctions! Gap junction is composed of 2 connexons (hemichannels), each made up of 6 connexin proteins! Information is bi-directional : chemical synapse chemical messenger crosses synaptic cleft! Structural diversity of chemical synapses: axon terminal signal transmission zone, receptor is close, axon varicosities release neurotransmitters, receptor is far, en passant synapse , spine synapse! Neurotransmitters: synthesized in neurons , released at presynaptic cell following depolarization (ca2+), bind to a postynaptic receptor to cause an effect, excitatory neurotransmitters cause depolarization of membrane! Makes postsynaptic cell more likely to generate an ap: inhibitory neurotransmitters cause hyper polarization of membrane! Friday, september 23, 2016: metabotropic receptors ! May lead to long-term changes via other cellular functions! Muscarinic receptor metabotropic, linked to ion channel function vis g-protein! Alpha (a): several isoforms (a1 and a2), metabotropic, linked to ion channel function via g-protein!

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The junction specialized for the transmission between a neuron and another cell is called a (1) _____ ______. Usually, the signal being sent to the receiving cell is carried by chemical messengers called (2) _____. (3) _____ is an example of this type of chemical messenger, which diffuses across the synaptic cleft, combines with protein receptor molecules on the muscle cell membrane, and soon thereafter is rapidly broken down by enzymes. At an (4) ____ synapse, the membrane potential is driven toward the threshold value and increases the likelihood that depolarization and an action potential will occur. At an (5) ____ synapse, the membrane potential is driven away form the threshold value, and the receiving neuron becomes hyperpolarized and is less likely to achieve an action potential. A specific transmitter substance can have either excitatory or inhibitory effects depending on which type of protein channel it opens up in the (6) ____ membrane. (7) ____ are neuromodulators that inhibit perceptions of pain and may have roles in memory and learning, emotional states, temperature regulation, and sexual behavior. (8) ____ ________ at the cellular level is the moment-by-moment tallying of all excitatory and inhibitory signals acting on a neuron. Incoming information is (9) ____ by the cell bodies, and the charge differences across the membranes are either enhanced or inhibited. Some narrow-diameter neurons are wrapped in lipid-rich (10) _______ produced by specialized neuroglial called Schwann cells; each of these is separated from the next by a(n) (11) ________ ________ - a small gap where the axon is exposed to extracellular fluid. A (12) ____ is an involuntary sequence of events elicited by a stimulus. During a (13) _______ ________, a muscle contracts involuntary whenever conditions cause a stretch in length; many of these help you maintain an upright posture despite small shifts in balance. Imbalances can occur at chemical synapses; a neurotoxin produced by Clostridium tetani blocks the release of GABA and glycine, thus freeing the motor neurons from (14) _____ control, which may cause tetanus â a prolonged, spastic paralysis that can lead to death. A. Excitatory H. Stretch reflex B. Inhibitory I. Summed C. Myelin J. Neurotransmitters D. Chemical synapse K. Postsynaptic E. Synaptic integration L. Endorphins F. Exposed node M. Acetylcholine (ACh)

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BIOLOGY 225 Lecture Notes - Lecture 8: Asthma, Mechanoreceptor, Stimulus Modality

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