BIOLOGY 225 Lecture Notes - Lecture 20: Signal Peptide, Catecholamine, Hydrophile

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2 Nov 2016
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Amine hormones: chemicals that possess amine group (-nh2)! Ex: acetylcholine, catecholamines (dopamine, norepinephrine, epinephrine), serotonin, melatonin, histamine and thyroid hormones: some true endocrine hormones, some neurotransmitters, some both, most hydrophilic ! Steroid hormones: derives from cholesterol, hydrophobic, cannot be stored, made on site, can diffuse through plasma membrane, synthesized by smooth er or mitochondria, three classes:! Reproductive hormones: bind to intracellular or transmembrane receptors, transported to target cell by carrier proteins! Ex: albumin: bind to intracellular or transmembrane receptors, slow effects on target cell (gene transcription)! Communication to the target cell: receptors on the target cell! Hydrophobic messengers bind to intracellular receptors: ligand! Chemical messenger that can bind to a speci c receptor: receptor changes shape when ligand binds! Ligand-receptor interactions: ligand binding causes a response, agonist binding causes a response! Can be man-made or a naturally occurring molecule : antagonist binding does not cause a response, a ligand may bind to more than one type of receptor!

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