IMMUNO 440 Lecture Notes - Lecture 15: T Helper 17 Cell, Immunosuppression, Tapeworm Infection
Document Summary
Long been suspected that different dc populations might be specialized for induction of different t-cell effector responses. Data have accumulated on dc functional heterogeneity, including dc subset- specific expression on prrs and production of signals involved in differentiation of. In addition, several transcriptional master regulators of dc lineages have been defined. Th1 cell-mediated immunity induced by batf3+ dcs. Th17 responses induced by mucosal irf4+ dcs and skin langerhans cells. Cell types involved in initiation and execution of immune response fall into o three categories: Cell types that function as sensors of infection or damage: Dcs and macrophages for type 1 immune responses. Epithelial cells and mast cells for type 2 immune responses. Different modes of recognition by the innate immune system induce. Level 1 cytokines act on second category of cells; these lymphocytes production of level 1 cytokines. Ifn- , il-17, il-22 for type 1 immune responses. Il-4, il-5, il-9, il-13 for type 2 immune responses.
