MCDB 310 Lecture Notes - Lecture 15: Citric Acid Cycle, Pyruvate Dehydrogenase Complex, Acetyl-Coa

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Citric acid cycle is far less regulated than glycolysis and is also known as the krebs cycle and the tricarboxylic acid cycle (tca). 3 carbon dioxides are liberated in this cycle. The intermediates of cac can go on to make amino acids, dna/rna, nicotinamides, protoporphyrin (heme ring), lipid things (steroids), vitamins cycle has to keep going in a circle to supply other tissues with the materials they need. You start the cac with an acetyl group. Nadh can generate more atp (2. 5) and fadh2 (1. 5) Thiamine deficiency: affects three multi-enzyme complexes that use tpp as a cofactor (thiamine pyrophosphate, pyruvate dehydrogenase complex (pdc, alpha-ketoglutarate dehydrogenase complex, transketolase. Second step: name: transformation of citrate to iso-citrate. Third step: name: the first decarboxylation & formation of nad(p)h, first formation of nadh, nadh in mitochondrial matrix, nadph in cytosol, enzyme: isocitrate dehydrogenase, reactions are dehydrogenases (hydrides, makes oxalosuccinate and intermediate is stabilized by manganese, order.

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